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Consistently male patients suffer severe Covid as compared to female patients. This led to a wrong conclusion that testosterone might be the culprit since men have more testosterone than women.
Serum samples were analyzed from Covid positive patients admitted between March to May 2020, at the Barnes Jewish Hospital, Missouri.
Testosterone, Estradiol and IGF-1 were measured at different time intervals to investigate if their concentrations in the blood was associated to severity of COVID19 and inflammation.
Higher levels of testosterone protected patients from severity of disease, and Low-T indicated severity of corona virus and inflammation.
This study which was probing if any connection exists between levels of sex hormones in the blood and acute Covid, found the opposite evidence. Testosterone protected men from causing severe corona virus. This was true taking into consideration age, race, comorbidities, BMI. Across the board it was found that low testosterone was a flag to severe disease even fatalities.
While the study did not prove that low testosterone in itself was the casual factor, it demonstrated that low-T was a definite indicator to issues that caused severe Covid.
This study was published in JAMA Open Network (Journal of The American Medical association) May 2021 edition. (citation & link to full article below).
A total of 152 patients were in the study, of which 9 were out patient. 143 patients were hospitalized. 90 men and 62 women participated.
For men only low testosterone correlated to severe COVID, while no correlation was found for women with respect to hormone levels or severity. Testosterone level during hospital admission for men averaged 53 nanograms per deciliter, while those with milder infection had average levels of 151 nanograms per deciliter. The average reduced to 19 for those who were very ill on third day.
Among women, no correlation found between levels of any hormone and disease severity.
Among men, only low testosterone levels were linked to COVID-19 severity. A blood testosterone level of 250 nanograms per deciliter or less is considered low-T in adult men. At hospital admission, men with severe COVID-19 had average T levels of 53 nanograms per deciliter; men with less severe disease had average levels of 151 nanograms per deciliter. By day three, the average testosterone level of the most severely ill men was only 19 nanograms per deciliter.
A clear pattern that emerged – lower the T levels, increased severity of disease and inflammation.
What with new mutations causing more out breaks, and further research ongoing on using testosterone as therapy, it might not be a bad idea to get testosterone levels tested if positive for corona virus, which might help with favorable outcomes and reduce severity and fatality in men from Covid?
Maybe, men suffering from comorbidities should test T levels as a preventive precaution even?
Dhindsa S, Zhang N, McPhaul MJ, et al. Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19. JAMA Netw Open. 2021;4(5):e2111398. doi:10.1001/jamanetworkopen.2021.11398
To get started with your testosterone levels testing, go to: ONMEN.CA/TRT